A monthly recap of the latest news about Alzheimer’s and dementia
Nearly half of dementia cases are preventable
The 2024 Lancet dementia report identified 14 key risk factors, plus two new ones, suggesting that 45 percent of dementia cases could be preventable with lifelong intervention. Read here.
TDP-43 function is lost a decade before LATE disease onset
Molecular and cellular changes associated with LATE, a form of dementia, begin a decade before the formation of abnormal clusters of TDP-43 that contribute to neurodegeneration and cognitive decline. Read here.
Scientists identify gene variant that may protect against APOE ε4-related Alzheimer’s risk
Certain versions of the fibronectin 1 gene may protect people with the APOE ε4 gene from increased Alzheimer’s disease risk, according to an NIA-funded study. Read here.
Role of glucose metabolism in Alzheimer’s disease
In Alzheimer’s disease, misfolded beta-amyloid and tau proteins accumulate in the brain. This leads to the progressive loss of connections between neurons. At the same time, glucose metabolism declines in certain types of brain cells, called astrocytes and microglia. Read here.
